Kipferon suppositories vaginal and rectal 200 mg + 500,000 IU 10 pcs. (immunoglobulin man Normal [IgG, IgM, IgA], interferon alfa-2b)

Release form

Suppositories.

Packing

10 pcs.

Pharmacological action of

Kipferon is a complex dosage form containing human recombinant interferon-β2 and a complex immunoglobulin preparation (CIP). Interferon- 2 is an activator of innate and acquired immunity, possesses pronounced antiviral activity, enhances protection against viral, chlamydial, mycoplasma and bacterial infections, has an immunomodulating effect in the development of immunological reactions, promotes the growth and preservation of the intestinal and vaginal normoflora.

The biological activity of interferon-β2 is realized through interaction with the receptor apparatus of immunocompetent and other cells, leading to increased expression of HLA I and HLA II molecules on the surface of all types of cells and the regulation of cell cooperation, increase the activity of natural killers, as well as giving intact cells resistance against their cytolytic action, proliferation of CD8 T cells. Increases the production of gamma interferon by natural killers. The complex immunoglobulin preparation KIP contains specific and non-specific immunoglobulins of classes G, M, A.

The combination of antiviral, antichlamydia, antibacterial and antitoxic antibodies belonging to different classes of immunoglobulins provides agglutination, neutralization and precipitation of etiotropic pathogenic agents. At the application site, it ensures stabilization of interferon from the secrets of the mucous membranes, normalizes local immunity due to the intake of IgA and IgM with suppositories (substitution effect), and increases the activity of locally formed cytokines.

Indications

The drug is used in the complex treatment of diseases accompanied by secondary immunodeficiency states: acute respiratory infections, respiratory diseases inflammatory diseases of the oropharynx of bacterial and viral etiology in children and adults

acute viral (rotavirus) and bacterial (salmonellosis, dysentery, coli infection) intestinal infections, including with manifestations of intestinal dysbiosis in children

urogenital chlamydia in women (including among pregnant women in the II-III trimesters of pregnancy), including those with manifestations of vaginal dysbiosis, vulvovaginitis, cervicitis of the uterus, cervical erosion.

Contraindications

Individual intolerance to individual components, pregnancy and lactation.

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation.

Composition

Ingredients:

iron (III) hydroxide polymaltose (equivalent to 100 mg of iron) folic acid 0.35 mg

Excipients:

dextrates

macrogol 6000

talc purified

sodium cyclamate

vanillin

f cocoa powder cocoa powder

fc cocoa powder

Active ingredients:

immunoglobulin complex preparation (CIP) - 0.2 g,

interferon alpha-2b human,

recombinant - 500 000 IU

Excipients:

special-purpose fat SolPro confectionery,

for chocolate Eliya and candies - 0.838 g,

solid paraffin oil P-2 - 0.085 g,

emulsifier "Hard" (T-2) - 0.085g,

disodium hydrogenphosphate dodecahydrate - 0,055mg,

sodium dihydrogen phosphate dihydrate - 0,018mg,

sodium chloride - 0.110 mg,

purified water - 0.012 g

Dosage and administration

Suppositories Kipferon is administered deeply intravaginally (before contact with the posterior vaginal fornix and cervix), 1-2 suppositories depending on the severity of the disease 2 times a day. The duration of treatment is an average of 10 days.

In the presence of cervical erosion, the use of the drug is continued until its epithelization.

If necessary, the course of treatment can be repeated.

In children, Kipferon suppositories are used taking into account the content of recombinant alpha-2 interferon in a daily dose of 500,000 ME (1 suppository), vaginally or rectally, in one dose, the course of treatment is 10 days. In girls with erased clinical forms of chlamydial vulvovaginitis and without clinical manifestations of the inflammatory process of the uterus and its appendages, chlamydial infection of the urinary tract, respiratory chlamydia treatment is carried out only against the background of vaginal and oral administration of eubiotics, in other cases, treatment of chlamydia in children with Kipferon suppositories is combined with the appointment of antibiotics and eubiotics.

Storage conditions

Store in a dry, dark place at a temperature of 6 to 8 ° C with a humidity of not more than 70%.

Shelf life

1 year.

Active ingredient

Normal human immunoglobulin [IgG, IgM, IgA], Interferon alfa-2b

Conditions for dispensing from pharmacies

Without a prescription

lekarstvennaja form

suppozytoryy rektaln e

Alfarm OOO, Russia



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